Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts 107
ORIGINAL ARTICLE
Year : 2021  |  Volume : 12  |  Issue : 2  |  Page : 86-89

Mucocutaneous side effects of gefitinib


1 Department of D&V, Government T D Medical College, Alappuzha, Kerala, India
2 Department of Radiotherapy, Government T D Medical College, Alappuzha, Kerala, India
3 Department of D&V, Government Medical College, Thiruvananthapuram, Kerala, India

Correspondence Address:
Dr. Rani Mathew
Department of D&V, Government Medical College, Thiruvananthapuram, Kerala
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mjmsr.mjmsr_48_21

Rights and Permissions

Background: Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein which is expressed in various tissues. Aberrant EGFR signaling plays an important role in carcinogenesis. Gefitinib, an EGFR inhibitor, is a promising drug in treatment of various malignancies. Awareness about the various mucocutaneous side effects of gefitinib will help in optimum management. Hence, we decided to conduct this study. Materials and Methods: We did a descriptive study and observed the various cutaneous side effects in 40 patients who were treated with gefitinib in a tertiary care center in South Kerala. Results: Dermatological adverse reactions were observed in 87.5% of our patients, the most common being dryness and pruritus in 67.5% and 65% of patients, respectively. Rashes were of Grade 1/2 severity in most of our cases. Conclusions: Cutaneous reactions, though common, were mild in majority of our patients. Studies with more sample size and follow-up are needed to improve our knowledge.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed354    
    Printed30    
    Emailed0    
    PDF Downloaded33    
    Comments [Add]    

Recommend this journal