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Year : 2016  |  Volume : 7  |  Issue : 2  |  Page : 136-140

Headache presenting as cerebral venous thrombosis associated with heterozygous methylenetetrahydrofolate reductase gene mutation: A case report

1 Department of Family Medicine, Lakeshore Hospital and Research Centre, Kochi, Kerala, India
2 Department of Neurology, Lakeshore Hospital and Research Centre, Kochi, Kerala, India

Correspondence Address:
Muhammed Jasim Abdul Jalal
Department of Family Medicine, Lakeshore Hospital and Research Centre, P.O. Nettoor, Maradu, NH 47 - Bypass, Ernakulam - 682 040, Kochi, Kerala
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0975-9727.185016

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Headache is among the most common pain problems encountered by the primary care physician. Cerebral venous thrombosis (CVT) is relatively rare in young adult males. Homocysteinemia is a significantly independent prothrombotic risk factor for atherogenic thrombotic cardiovascular, cerebrovascular, and peripheral vascular diseases. Methylenetetrahydrofolate reductase (MTHFR) gene mutation results in high serum homocysteine levels. Here, we report a 45-year-old male who presented with acute onset severe headache. Brain imaging showed thrombosis of superior sagittal sinus. The level of serum homocysteine was elevated and there was heterozygous CG677T polymorphism of the MTHFR gene.

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