| ORIGINAL ARTICLE |
|
| Year : 2013 | Volume
: 4
| Issue : 2 | Page : 74-77 |
|
|
A hospital-based study of anti-TPO titer in patients with thyroid disease
E Jacob Jeena1, M Malathi1, K Sudeep2
1 Department of Biochemistry, Father Muller Medical College, Kankanady, Mangalore, Karnataka, India
2 Department of Endocrinology, Father Muller Medical College, Kankanady, Mangalore, Karnataka, India
Correspondence Address:
M Malathi
Department of Biochemistry, Father Muller Medical College, Kankanady, Mangalore - 575 002, Karnataka
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0975-9727.118228
|
|
|
Context: Autoimmunity against the thyroid gland is one of the most important causes for thyroid dysfunction. Anti-thyroid antibody test is an important tool in the evaluation of autoimmune thyroid disorders. Aims: To study the prevalence of thyroid hormone dysfunction and positive anti-TPO antibody titers in patients being evaluated for thyroid-related disorders. Settings and Design:This retrospective cross-sectional study was done in Father Muller Medical College. Materials and Methods: The TSH (Thyroid stimulating hormone), FT 4 (Free thyroxine), and anti-TPO titer reports of 74 subjects undergoing evaluation for thyroid-related disorders were analyzed. Statistical Analysis Used: Statistical significance was estimated by P value. Results: About two-third (60%) of hypothyroid patients showed raised TPO antibody titer. The titer was significantly higher in hypothyroid subjects when compared to the euthyroid subjects, and a majority of the hypothyroid subjects had a titer at least twice the upper limit of normal. Two of the three subjects with hyperthyroidism also had elevated anti-TPO titers. Conclusions: The commonest cause of hypothyroidism in our study subjects was autoimmune-related thyroid disease. Anti-TPO antibody estimation is a very useful test for establishing the etiological diagnosis of autoimmune thyroid diseases in our population. In situations where there is a diffuse non-progressive goiter, anti-TPO antibody estimation can substitute for an invasive FNAC. |
|
|
|
| [FULL TEXT] [PDF]* |
|
 |
|
