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Year : 2013  |  Volume : 4  |  Issue : 1  |  Page : 45

Neurofibromatosis type 1

Department of Dermatology, Father Muller Medical College, Mangalore, India

Date of Web Publication20-May-2013

Correspondence Address:
P Chaitra
Department of Dermatology, Father Muller Medical College, Mangalore
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0975-9727.112292

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How to cite this article:
Chaitra P, Bhat M R. Neurofibromatosis type 1. Muller J Med Sci Res 2013;4:45

How to cite this URL:
Chaitra P, Bhat M R. Neurofibromatosis type 1. Muller J Med Sci Res [serial online] 2013 [cited 2023 Mar 20];4:45. Available from: https://www.mjmsr.net/text.asp?2013/4/1/45/112292

A 22-year-old female with insignificant family history presented with progressive asymptomatic swellings all over the body which first appeared at the age of 10. Innumerable skin-colored nodules and pedunculated tumors of sizes varying from few millimeters to as large as 10 centimeters in diameter and multiple tan brown macules of size >15 mm were noted on examination. Diagnosis of neurofibroma [Figure 1]a-e and café-au-lait macules (CALMs) [Figure 2] was confirmed on histopathology. The disease was classified as neurofibromatosis type 1 (NF 1) based on NIH criteria. [1]
Figure 1 (a-e): Cutaneous neurofibromas

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Figure 2: Cafe‑au‑lait macule

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NF 1 (von Recklinghausen disease), the commonest of 8 types of NF is described as an autosomal dominant multisystem disorder with an incidence of 1 in 3500 population. Cutaneous neurofibromas (mollusca fibrosa) are benign tumors arising from Schwann cells of the peripheral nerves and their supporting structures in the dermis, the close differential diagnosis of which includes nodules of histoid leprosy.

  References Top

1.Neurofibromatosis. Conference statement. National Institutes of Health Consensus Development Conference. Arch Neurol 1988;45:575-8.  Back to cited text no. 1


  [Figure 1], [Figure 2]


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