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| MEDICAL IMAGE |
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| Year : 2013 | Volume
: 4
| Issue : 1 | Page : 45 |
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Neurofibromatosis type 1
P Chaitra, M Ramesh Bhat
Department of Dermatology, Father Muller Medical College, Mangalore, India
| Date of Web Publication | 20-May-2013 |
Correspondence Address:
P Chaitra
Department of Dermatology, Father Muller Medical College, Mangalore
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0975-9727.112292
How to cite this article:
Chaitra P, Bhat M R. Neurofibromatosis type 1. Muller J Med Sci Res 2013;4:45 |
A 22-year-old female with insignificant family history presented with progressive asymptomatic swellings all over the body which first appeared at the age of 10. Innumerable skin-colored nodules and pedunculated tumors of sizes varying from few millimeters to as large as 10 centimeters in diameter and multiple tan brown macules of size >15 mm were noted on examination. Diagnosis of neurofibroma [Figure 1]a-e and café-au-lait macules (CALMs) [Figure 2] was confirmed on histopathology. The disease was classified as neurofibromatosis type 1 (NF 1) based on NIH criteria. [1]
NF 1 (von Recklinghausen disease), the commonest of 8 types of NF is described as an autosomal dominant multisystem disorder with an incidence of 1 in 3500 population. Cutaneous neurofibromas (mollusca fibrosa) are benign tumors arising from Schwann cells of the peripheral nerves and their supporting structures in the dermis, the close differential diagnosis of which includes nodules of histoid leprosy.
| References | |  |
| 1. | Neurofibromatosis. Conference statement. National Institutes of Health Consensus Development Conference. Arch Neurol 1988;45:575-8. 
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[Figure 1], [Figure 2]
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